He also didn’t dis medical marijuana when he got the chance. Other than that, it’s just typical O’Reilly bloviation, but worth the watch. His main line of attack was the George Soros connection, described by Jacob Sullum this way:
Since the book’s anti-prohibition message is not exactly subtle, it’s odd that O’Reilly latches on to Cortes’ expression of thanks to George Soros, a major patron of the drug policy reform movement, as evidence of the author’s support for marijuana legalization. Cortes, for his part, is weirdly evasive about why he thanked Soros (the book was supported by two Soros-funded groups, the Marijuana Policy Project and the Drug Policy Alliance) and what he thinks about the drug laws, although he eventually says he has a legalization plan that may or may not be similar to the one Soros supports.
Be sure to listen for the Clinton-like I didn’t swallow line.